This report is submitted as a follow-up to the pledges I made during the Joint African Union (AU) Commission – Permanent Representatives Committee (PRC) Retreat, held in Cairo, Egypt, from 10 to 11 December 2017, and the interaction I had with the PRC on 7 March 2018. The report covers issues relating to the establishment and governance structure of the Africa Centre for Disease Control (Africa CDC), as well as the activities undertaken, including challenges encountered. It concludes with recommendations on the way forward.